期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 11, 期 2, 页码 198-215出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920110790909641
关键词
Protein misfolding; neuroprotection; proteinopathies; molecular chaperones
资金
- Medical Research Council (MRC, UK)
- BBSRC
- Gerald Kerkut Trust
- University of Southampton
- Medical Research Council [G120/881] Funding Source: researchfish
- MRC [G120/881] Funding Source: UKRI
Intra- and extracellular protein misfolding and aggregation is likely to contribute to a number of age-related central nervous system diseases (proteinopathies). Therefore, molecular chaperones, such as heat shock proteins (HSPs), that regulate protein folding, misfolding and adaption to cellular stress are emerging as therapeutic targets. Here we review the current knowledge of HSP-modulating drugs and discuss the opportunities and difficulties of their therapeutic use to treat proteinopathies such as Alzheimer's-and Parkinson's disease, the polyglutamine-and prion disorders and Amyotrophic Lateral Sclerosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据