期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 11, 期 2, 页码 139-145出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920110790909704
关键词
Aging; caloric restriction; diabetes; heat shock response; resveratrol; sirtuin
资金
- EU [FP6-518230, PROTEOMAGE, FP7-200970, WhyWeAge]
- Hungarian Science Foundation [OTKA K69105, NNF-78794]
Molecular chaperones and the heat shock response guard and modulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellar networks. Overnutrition and the metabolic syndrome represent a pro-aging condition, and dietary restriction is the most robust environmental intervention that induces longevity from yeast to mammals. In recent years a considerable effort has been made to elucidate the signaling pathways involved in metabolic signaling. Here we review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders.
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