期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 9, 期 4, 页码 249-252出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920108785161569
关键词
cancer; metastasis; CD44; signaling; apoptosis
资金
- NCRR NIH HHS [P20 RR016434] Funding Source: Medline
Hyaluronan (HA) polysaccharide has differential effects on cells depending on polymer size. One of the more exciting findings is that small chains or oligosaccharides of HA (6-18 sugar units), but not large polymers, will kill many types of cancer cells by triggering apoptosis while leaving normal cells unaffected. Even chemoresistant cells become drug-sensitive when co-treated with HA oligosaccharides. Overall, these observations form the basis for new anticancer therapeutics.
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