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Pathophysiology and treatment of painful diabetic neuropathy

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CURRENT PAIN AND HEADACHE REPORTS
卷 12, 期 3, 页码 192-197

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CURRENT SCIENCE INC
DOI: 10.1007/s11916-008-0034-1

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Diabetes is the most common cause of peripheral neuropathy, and painful diabetic neuropathy (PDN) affects approximately 30% of diabetic patients with neuropathy. It is extremely distressing for the patient and poses significant management difficulties because no treatment provides total relief, and side effects of therapy are a major limiting factor for titrating therapy. Understanding the pathogenesis of diabetic neuropathy may lead to the development of new treatments to prevent nerve damage, and a better understanding of the mechanisms that modulate pain may lead to more effective relief of painful symptoms. We provide an update on the pathogenesis, diagnosis, and treatment of PDN.

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