Synthesis, Structure and Application of α,β-Dehydro-α-aminophosphonic and α,β Dehydro-α-aminophosphinic Acid Derivatives

The synthesis of alpha, beta-dehydro-alpha -aminophosphonic and alpha, beta-dehydro-alpha-aminophosphinic acid derivatives is discussed. The most important synthetic pathways to the above-mentioned compounds have been divided into four groups depending on the type of bond formed as the last one. The configuration at the C= C double bond can be established based on the specific coupling constants (3)J(HP) and (3)J(CP) for the appropriate Z-and E-stereoisomers. The application of alpha, beta-dehydro-alpha-aminophosphonates and alpha, beta-dehydro-alpha-aminophosphinates, particularly in the enantioselective catalytic hydrogenation, is also discussed.