期刊
CURRENT ORGANIC CHEMISTRY
卷 18, 期 3, 页码 359-406出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13852728113179990025
关键词
N-Alkylation; cyclization; heterocyclic transformation; hydrazine; hydrazone; N-quaternization; structural modification; 1,2,4-triazole
资金
- National Natural Science Foundation of China [21172181, 21004075, 21372186, 81350110338, 81250110089, 81250110554]
- Key Program from Natural Science Foundation of Chongqing [CSTC2012jjB10026]
- Specialized Research Fund for the Doctoral Program of Higher Education of China (SRFDP) [20110182110007]
- Fundamental Research Funds for the Central Universities [XDJK2011D007, XDJK2012B026]
- Doctoral Fund of Southwest University [SWU111075, SWUB2006018]
Heterocyclic 1,2,4-triazole derivatives possess unusually spacious potentiality as medicinal agents, agricultural chemicals, functional materials, ionic liquids, supramolecular catalysts as well as artificial enzymes and receptors for supramolecular recognition and biomimetic catalysis, and their various researches and developments have been being a quite rapidly developing and active highlight topic with an infinite space. Numerous efforts have been directed toward various types of possible applications of 1,2,4-triazole-based compounds and a lot of important progress has been made, especially their preparations have attracted increasing attention. This review systematically summarized the recent advances in the syntheses of 1,2,4-triazole derivatives, including: (1) Cyclizations to form triazole ring; (2) Transformations of heterocyclic compounds to construct triazole ring; (3) Substitutions on 1,2,4-triazole ring; (4) Structural modifications in side chains of 1,2,4-triazole ring. It was hoped that this review would be helpful for the design and development of highly efficient preparation of 1,2,4-triazole derivatives with various sorts and varieties of extensively potential applications in medicine, agriculture, chemistry, materials, supramolecular sciences and so on.
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