期刊
CURRENT ORGANIC CHEMISTRY
卷 15, 期 10, 页码 1482-1506出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138527211795378137
关键词
Amines; asymmetric synthesis; nitroalkanes; nucleophilic additions; reductions
资金
- University of Camerino
- Italian MIUR
The carbanion stabilizing effect of the nitro group makes nitroalkanes ideal reagents in carbon-carbon bond formation. Once introduced in a molecular framework, the nitro group is amenable to further transformations including reduction to primary amines. The aim of this review is to explore the utilization of nitroalkanes as effective substrates for the preparation of important target compounds featured by the amino group. These will include simple primary amines, diamines, amino acids, piperidines, pyrrolidines and heteroaromatic derivatives. A particular emphasis will be placed on the synthesis of enantioenriched amino derivatives mediated by organocatalysts or organometallic complexes.
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