期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 52, 期 -, 页码 58-63出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.08.008
关键词
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资金
- NIH [R01GM082893, R01GM098672, R01HL134183, P50GM082250, P01GM111126, S10OD020054, S10OD021741]
In the past few years, significant technological breakthroughs in single particle cryo-electron microscopy enabled a `resolution revolution' of this technique. It also changed structural biology in an 'unprecedented way. For many biological macromolecules, obtaining well-ordered crystals of suitable size is no longer a prerequisite for determining their atomic structures. One of the most impacted areas is the structural biology of integral membrane proteins. New structures are now determined at a rapid pace. Despite these advances, further technological developments are still required to overcome new technical challenges that face membrane protein structural biology. In this review, I attempt to discuss some of these challenges.
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