期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 51, 期 -, 页码 195-202出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.07.009
关键词
-
资金
- National Institutes of Health [R01 GM086487]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM086487] Funding Source: NIH RePORTER
Many tail-anchored (TA) membrane proteins are targeted to and inserted into the endoplasmic reticulum (ER) by the 'guided entry of tail-anchored proteins' (GET) pathway. This post translational pathway uses transmembrane-domain selective cytosolic chaperones for targeting, and a dedicated membrane protein complex for insertion. The past decade has seen rapid progress towards defining the molecular basis of TA protein biogenesis by the GET pathway. Here we review the mechanisms underlying each step of the pathway, emphasizing recent structural work and highlighting key questions that await future studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据