期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 25, 期 -, 页码 34-39出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2013.11.012
关键词
-
资金
- Slovenian Research Agency [P1-0002]
- Fulbright Grant
While structural genomics resulted in thousands of new protein crystal structures, we still do not know the functions of most of these proteins. One reason for this shortcoming is their unique sequences or folds, which leaves them assigned as proteins of 'unknown function'. Recent advances in and applications of cutting edge binding site comparison algorithms for binding site detection and function prediction have begun to shed light on this problem. Here, we review these algorithms and their use in function prediction and pharmaceutical discovery. Finding common binding sites in weakly related proteins may lead to the discovery of new protein functions and to novel ways of drug discovery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据