期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 25, 期 -, 页码 77-85出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2014.01.007
关键词
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资金
- JC Bose National Fellowship of DST, India
D Regulatory information for transcription initiation is present in a stretch of genomic DNA, called the promoter region that is located upstream of the transcription start site (TSS) of the gene. The promoter region interacts with different transcription factors and RNA polymerase to initiate transcription and contains short stretches of transcription factor binding sites (TFBSs), as well as structurally unique elements. Recent experimental and computational analyses of promoter sequences show that they often have non-B-DNA structural motifs, as well as some conserved structural properties, such as stability, bendability, nucleosome positioning preference and curvature, across a class of organisms. Here, we briefly describe these structural features, the differences observed in various organisms and their possible role in regulation of gene expression.
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