期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 29, 期 -, 页码 95-101出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2014.10.002
关键词
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资金
- NIH [R01-CA079992, F32-GM109688]
- NIH Training Grant in Structural Biology [T32-GM008275]
- Predoctoral Fellowship from the Great Rivers Affiliate of the American Heart Association [10PRE4140108]
Numerous crystal structures have been reported for the isolated extracellular region and tyrosine kinase domain of the epidermal growth factor receptor (EGFR) and its relatives, in different states of activation and bound to a variety of inhibitors used in cancer therapy. The next challenge is to put these structures together accurately in functional models of the intact receptor in its membrane environment. The intact EGFR has been studied using electron microscopy, chemical biology methods, biochemically, and computationally. The distinct approaches yield different impressions about the structural modes of communication between extracellular and intracellular regions. They highlight possible differences between ligands, and also underline the need to understand how the receptor interacts with the membrane itself.
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