期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 25, 期 -, 页码 92-97出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2014.01.006
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资金
- NIH grants (ADM) from the National Institute for General Medical Sciences
- National Heart Lung and Blood Institute
- Evita programme of the Research Council of Norway
- Research Council of Norway to the Center for Biomedical Computing at Simula Research Laboratory
- AHA award [13POST14510036]
Numerous signaling processes in the cell are controlled in microdomains that are defined by cellular structures ranging from nm to mu m in size. Recent improvements in microscopy enable the resolution and reconstruction of these micro domains, while new computational methods provide the means to elucidate their functional roles. Collectively these tools allow for a biophysical understanding of the cellular environment and its pathological progression in disease. Here we review recent advancements in microscopy, and subcellular modeling on the basis of reconstructed geometries, with a special focus on signaling microdomains that are important for the excitation contraction coupling in cardiac myocytes.
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