期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 29, 期 -, 页码 58-66出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2014.09.006
关键词
-
资金
- National Institutes of Health [R01 GM 058822, R01 GM 079038]
Lanthipeptides are members of the ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. They contain thioether crosslinks generated by dehydration of Ser and Thr residues followed by the addition of the thiol of Cys residues to the dehydroamino acids. Recent studies have revealed unexpected mechanisms of the post-translational modifications, and structural studies have started to provide insights into recognition of the peptide substrates by the modification enzymes.
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