期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 23, 期 5, 页码 788-793出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2013.06.018
关键词
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资金
- Netherlands Organization for Scientific Research (NWO) [Vici 680-47-607]
- European Research Council [ERC Starting 281098]
Recent advances in the development of single-molecule approaches have made it possible to study the dynamics of biomolecular systems in great detail. More recently, such tools have been applied to study the dynamic nature of large multiprotein complexes that support multiple enzymatic activities. In this review, we will discuss single-molecule studies of the replisome, the protein complex responsible for the coordinated replication of double-stranded DNA. In particular, we will focus on new insights obtained into the dynamic nature of the composition of the DNA-replication machinery and how the dynamic replacement of components plays a role in the regulation of the DNA-replication process.
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