期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 23, 期 5, 页码 686-694出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2013.09.002
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资金
- National Science and Engineering Research Council of Canada [RGPIN 398508]
- Israel Science Foundation [1349/13]
Cellulosomes are multi-enzyme complexes produced by anaerobic bacteria for the efficient deconstruction of plant cell wall polysaccharides. The assembly of enzymatic subunits onto a central non-catalytic scaffoldin subunit is mediated by a highly specific interaction between the enzyme-bearing dockerin modules and the resident cohesin modules of the scaffoldin, which affords their catalytic activities to work synergistically. The scaffoldin also imparts substrate-binding and bacterial-anchoring properties, the latter of which involves a second cohesin-dockerin interaction. Recent structure-function studies reveal an ever-growing array of unique and increasingly complex cohesin-dockerin complexes and cellulosomal enzymes with novel activities. A 'build' approach involving multimodular cellulosomal segments has provided a structural model of an organized yet conformationally dynamic supramolecular assembly with the potential to form higher order structures.
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