期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 21, 期 1, 页码 109-118出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.10.009
关键词
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资金
- Biotechnology and Biological Sciences Research Council (UK)
- Wellcome Trust (UK)
- Biotechnology and Biological Sciences Research Council [BB/H002677/1] Funding Source: researchfish
- BBSRC [BB/H002677/1] Funding Source: UKRI
Many prokaryotes express toxin-antitoxin (TA) pairs that are harmful to their hosts if not maintained in delicate balance. The maintenance of potentially lethal toxin-antitoxin pairs could be viewed as a high-risk strategy. However, accumulating evidence suggests that toxin-antitoxin pairs can confer selective evolutionary benefits such as adaptive stress responses, starvation recovery and herd immunity to predation. Many of the known TA pairs interact as proteins, but recent work has identified a new class of antitoxins that are RNA cleavage products. Structural studies have revealed common folds for diverse toxins, highlighting unexpected evolutionary relationships within different toxin classes. TA pairs appear to have diverged in function considerably, to meet the specialised requirements of their varied prokaryotic hosts.
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