期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 21, 期 3, 页码 432-440出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2011.03.011
关键词
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资金
- MRC
- HFSP [RGY0073/2010]
- PrioNet Canada
- University of British Columbia
- FEBS Long-Term fellowship
- MRC [MC_U105185859] Funding Source: UKRI
- Medical Research Council [MC_U105185859] Funding Source: researchfish
Intrinsically disordered proteins (IDPs) are enriched in signaling and regulatory functions because disordered segments permit interaction with several proteins and hence the re-use of the same protein in multiple pathways. Understanding IDP regulation is important because altered expression of IDPs is associated with many diseases. Recent studies show that IDPs are tightly regulated and that dosage-sensitive genes encode proteins with disordered segments. The tight regulation of IDPs may contribute to signaling fidelity by ensuring that IDPs are available in appropriate amounts and not present longer than needed. The altered availability of IDPs may result in sequestration of proteins through non-functional interactions involving disordered segments (i.e., molecular titration), thereby causing an imbalance in signaling pathways. We discuss the regulation of IDPs, address implications for signaling, disease and drug development, and outline directions for future research.
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