期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 20, 期 2, 页码 234-240出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.01.009
关键词
-
资金
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
Nonribosomal peptide synthetases (NRPSs) are large multimodular biocatalysts that utilize complex regiospecific and stereospecific reactions to assemble structurally and functionally diverse peptides that have important medicinal applications. During this ribosome-independent peptide synthesis, catalytic domains of NRPS select, activate or modify the covalently tethered reaction intermediates to control the iterative chain elongation process and product release. Recent advances in structural elucidation of domains, didomains, and an entire termination module revealed valuable insights into the mechanism of nonribosomal synthesis and are highlighted herein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据