期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 20, 期 6, 页码 749-755出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.09.014
关键词
-
资金
- French Medical Research Foundation (FRM) [DEQ20090515390]
- European Commission [LSHM-CT-2004-512138]
- Rhone-Alpes region
- Centro Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq Brasil) [202027/2007-4]
The bacterial cell wall is a complex three-dimensional structure that protects the cell from environmental stress and ensures its shape. The biosynthesis of its main component, the peptidoglycan, involves the coordination of activities of proteins present in the cytoplasm, the membrane, and the periplasm, some of which also interact with the bacterial cytoskeleton. The sheer complexity of the cell wall elongation process, which is the main focus of this review, has created a significant challenge for the study of the macromolecular interactions that regulate peptidoglycan biosynthesis. The availability of new structural and biochemical data on a number of components of peptidoglycan assembly machineries, including a complex between MreB and RodZ as well as structures of penicillin-binding proteins (PBPs) from a number of pathogenic species, now provide novel insight into the underpinnings of an intricate molecular machinery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据