期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 20, 期 6, 页码 763-771出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.09.010
关键词
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资金
- Spanish Ministry of Science and Innovation [BIO2009-10872, BFU2008-05021]
- Generalitat Valenciana [Prometeo/2009/051]
- CIBERER
Two-component systems, composed of a homodimeric histidine kinase (HK) and a response regulator (RR), are major signal transduction devices in bacteria. Typically the signal triggers HK autophosphorylation at one His residue, followed by phosphoryl transfer from the phospho-His to an Asp residue in the RR. Signal extinction frequently involves phospho-RR dephosphorylation by a phosphatase activity of the HK. Our understanding of these reactions and of the determinants of partner specificity among HK-RR couples has been greatly increased by recent crystal structures and biochemical experiments on HK-RR complexes. Cis-autophosphorylation (one subunit phosphorylates itself) occurs in some HKs while trans-autophosphorylation takes place in others. We review and integrate this new information, discuss the mechanism of the three reactions and propose a model for transmembrane signaling by these systems.
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