期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 20, 期 6, 页码 722-729出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.09.007
关键词
-
资金
- Jay and Betty Van Andel Foundation
- National Institute of Health [HL089301, GM087413, DK071662, DK066202]
Abscisic acid (ABA) is a plant hormone with important functions in stress protection and physiology. Recently, the PYR/PYL/RCAR family of intracellular ABA receptors was identified. These receptors directly link ABA perception to a canonical ABA signaling pathway, in which ABA-bound receptors bind and inhibit type 2C phosphatases. High resolution crystal structures of members of this family have been solved in all relevant states: as apo receptors, bound to ABA, and as receptor-ABA-phosphatase complexes. Together, these structures provide a detailed gate-latch-lock mechanism of ABA recognition, receptor-PP2C interaction, and inhibition of the PP2C phosphatase activity and provide a basis for the design of synthetic ABA agonists for stress protection of crop plants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据