期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 18, 期 6, 页码 756-764出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.10.002
关键词
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资金
- National Institutes of Health [R01 LM007688-01A1, GM071714-01A2]
The application of bioinformatics methodologies to proteins inherently lacking 3D structure has brought increased attention to these macromolecules. Here topics concerning these proteins are discussed, including their prediction from amino acid sequence, their enrichment in eukaryotes compared to prokaryotes, their more rapid evolution compared to structured proteins, their organization into specific groups, their structural preferences, their half-lives in cells, their contributions to signaling diversity (via high contents of multiple-partner binding sites, post-translational modifications, and alternative splicing), their distinct functional repertoire compared to that of structured proteins, and their involvement in diseases.
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