期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 18, 期 6, 页码 734-740出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.09.010
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资金
- [GM56169]
- [NS028471]
- [GM075811]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R21GM075811, R01GM056169] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS028471, R37NS028471] Funding Source: NIH RePORTER
G-protein-coupled receptors (GPCRs) are the largest family of eukaryotic plasma membrane receptors, and are responsible for the majority of cellular responses to external signals. GPCRs share a common architecture comprising seven transmembrane (TM) helices. Binding of an activating ligand enables the receptor to catalyze the exchange of GTP for GDP in a heterotrimeric G protein. GPCRs are in a conformational equilibrium between inactive and activating states. Crystallographic and spectroscopic studies of the visual pigment rhodopsin and two beta-adrenergic receptors have defined some of the conformational changes associated with activation.
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