期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 18, 期 3, 页码 382-386出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.03.007
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
Multiple sequence alignments are essential in computational analysis of protein sequences and structures, with applications in structure modeling, functional site prediction, phylogenetic analysis and sequence database searching. Constructing accurate multiple alignments for divergent protein sequences remains a difficult computational task, and alignment speed becomes an issue for large sequence datasets. Here, I review methodologies and recent advances in the multiple protein sequence alignment field, with emphasis on the use of additional sequence and structural information to improve alignment quality.
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