期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 18, 期 5, 页码 617-622出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.07.004
关键词
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资金
- Australian Research Council (ARC)
- Monash Centre for Synchrotron Science Fellow
- ARC Federation Fellow
- National Health and Medical Research Council (NHMRC)
High-resolution techniques are the mainstay of structural biologists; however, to address challenging biological systems many are now turning to hybrid approaches that use complementary structural data. In this review we outline the types of structural problems that benefit from combining results of many methods, we summarise the types of data that can be generated by complementary approaches, and we highlight the application of combined methods in structural biology with recent structural studies of membrane proteins, mega-complexes and inherently flexible proteins.
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