期刊
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
卷 16, 期 6, 页码 323-332出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cossms.2013.01.001
关键词
Cancer; PLA; PLGA; Drug delivery; Nanomedicine; Chemotherapeutics; Polymer-drug conjugates; Nanoconjugates
资金
- NCI NIH HHS [R21 CA152627] Funding Source: Medline
- NIH HHS [DP2 OD007246] Funding Source: Medline
Small molecule chemotherapeutics often have undesired physiochemical and pharmacological properties, such as low solubility, severe side effect and narrow therapeutic index. To address these challenges, polymeric nanomedicine drug delivery technology has been routinely employed, in particular with the use of biodegradable and biocompatible polyesters, such as poly(lactide) (PLA) and poly(lactide-co-glycolide) (PLGA). Here we review the development and use of PLA and PLGA for the delivery of chemotherapeutic agents in the forms of polymer-drug conjugates and nanoconjugates. (C) 2013 Elsevier Ltd. All rights reserved.
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