Clinical implications of pathogenic calcium crystals

Purpose of reviewThe role of intraarticular calcifications has been challenged over the past years, with respect to cartilage destruction, especially in osteoarthritis.Recent findingsMain themes reviewed in this article will discuss prevalence of articular cartilage calcifications, mechanisms of cartilage calcifications, and mostly the pathogenic role of both calcium pyrophosphate and basic calcium phosphate crystals.SummaryA direct pathogenic role of both calcium crystals has been depicted, in cartilage as a crystal-induced stress, or via acute or chronic crystal-induced synovitis.