4.4 Review

Myofibroblasts

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Recent Developments in Myofibroblast Biology Paradigms for Connective Tissue Remodeling

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Mesenchymal-Specific Deletion of C/EBPβ Suppresses Pulmonary Fibrosis

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Hedgehog-Gli Pathway Activation during Kidney Fibrosis

Steven L. Fabian et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

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Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis

Elizabeth R. Davies et al.

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Article Rheumatology

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

Angelika Horn et al.

ARTHRITIS AND RHEUMATISM (2012)

Article Biochemistry & Molecular Biology

Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet

Shingo Akita et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Article Genetics & Heredity

Global analysis of DNA methylation in early-stage liver fibrosis

Yoko Komatsu et al.

BMC MEDICAL GENOMICS (2012)

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Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

Ross McMillan et al.

CLINICAL CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Joy X. Jiang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Urology & Nephrology

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

Hong Ding et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2012)

Article Medicine, Research & Experimental

Wnt signaling induces epithelial-mesenchymal transition with proliferation in ARPE-19 cells upon loss of contact inhibition

Hung-Chi Chen et al.

LABORATORY INVESTIGATION (2012)

Article Multidisciplinary Sciences

Global Methylation Patterns in Idiopathic Pulmonary Fibrosis

Einat I. Rabinovich et al.

PLOS ONE (2012)

Article Gastroenterology & Hepatology

Notch3 regulates the activation of hepatic stellate cells

Yi-Xiong Chen et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2012)

Article Multidisciplinary Sciences

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

Alfiya Akhmetshina et al.

NATURE COMMUNICATIONS (2012)

Review Neurosciences

Regulation of thalamic development by Sonic hedgehog

Douglas J. Epstein

FRONTIERS IN NEUROSCIENCE (2012)

Review Pathology

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

Sonsoles Piera-Velazquez et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Biochemistry & Molecular Biology

Epigenetic Regulation of Thy-1 by Histone Deacetylase Inhibitor in Rat Lung Fibroblasts

Yan Y. Sanders et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)

Article Rheumatology

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

Clara Dees et al.

ANNALS OF THE RHEUMATIC DISEASES (2011)

Review Physiology

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

Harold A. Chapman

ANNUAL REVIEW OF PHYSIOLOGY, VOL 73 (2011)

Article Biochemistry & Molecular Biology

A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

Stephanie Carnesecchi et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Article Oncology

Reversible differentiation of myofibroblasts by MyoD

Louise Hecker et al.

EXPERIMENTAL CELL RESEARCH (2011)

Review Biochemistry & Molecular Biology

The role of Hedgehog signaling in fibrogenic liver repair

Steve S. Choi et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)

Review Pathology

Fibroblasts and myofibroblasts in renal fibrosis

Soma Meran et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2011)

Article Medicine, Research & Experimental

Absence of Thy-1 results in TGF-β induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts

Gustavo Ramirez et al.

LABORATORY INVESTIGATION (2011)

Article Multidisciplinary Sciences

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

Jason R. Rock et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Editorial Material Biochemistry & Molecular Biology

Focus Issue: Fine-Tuning Hedgehog Signaling in Development and Disease

Annalisa M. VanHook

SCIENCE SIGNALING (2011)

Article Medicine, General & Internal

Blockade of the Wnt/beta-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis

Tae Hyung Kim et al.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Review Medical Laboratory Technology

MicroRNAs in idiopathic pulmonary fibrosis

Kusum V. Pandit et al.

TRANSLATIONAL RESEARCH (2011)

Article Pathology

Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation

Biao Hu et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Pathology

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

Benjamin D. Humphreys et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Article Biochemistry & Molecular Biology

Nkx2.5/Csx Represses Myofibroblast Differentiation

Biao Hu et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

MicroRNA-155 regulates angiotensin II type 1 receptor expression and phenotypic differentiation in vascular adventitial fibroblasts

Liang Zheng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

Article Gastroenterology & Hepatology

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

Jelena Mann et al.

GASTROENTEROLOGY (2010)

Article Immunology

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

Gang Liu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Urology & Nephrology

NAD(P)H Oxidase Mediates TGF-beta 1-Induced Activation of Kidney Myofibroblasts

Corry D. Bondi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Pathology

Notch1 Signaling in FIZZ1 Induction of Myofibroblast Differentiation

Tianju Liu et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

Article Physiology

Abrogation of TGF-β1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition

Weichao Guo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2009)

Article Critical Care Medicine

Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis

Harikrishna Tanjore et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)

Review Biochemistry & Molecular Biology

Epithelial-Mesenchymal Transitions in Development and Disease

Jean Paul Thiery et al.

Editorial Material Cardiac & Cardiovascular Systems

Regulation of myofibroblast differentiation by convergence of the Wnt and TGF-beta 1/Smad signaling pathways

Sarah Jane George

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

Article Biochemistry & Molecular Biology

NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury

Louise Hecker et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

Thy-1 Promoter Hypermethylation A Novel Epigenetic Pathogenic Mechanism in Pulmonary Fibrosis

Yan Y. Sanders et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Transforming growth factor-β(TGF-β1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression

Simone Kennard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

Muller Fabbri et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Pathology

The myofibroblast - One function, multiple origins

Boris Hinz et al.

AMERICAN JOURNAL OF PATHOLOGY (2007)

Article Cell Biology

Cx43 mediates TGF-β signaling through competitive Smads binding to microtubules

Ping Dai et al.

MOLECULAR BIOLOGY OF THE CELL (2007)

Article Cell Biology

Notch2 negatively regulates myofibroblastic differentiation of myoblasts

Yusuke Ono et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2007)

Review Dermatology

Formation and function of the myofibroblast during tissue repair

Boris Hinz

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2007)

Article Gastroenterology & Hepatology

Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis

Tatiana Kisseleva et al.

JOURNAL OF HEPATOLOGY (2006)

Article Multidisciplinary Sciences

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

Kevin K. Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Physiology

Chloride channel activity in human lung fibroblasts and myofibroblasts

ZH Yin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Physiology

PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production:: implications for therapy of lung fibrosis

HA Burgess et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)

Article Cell Biology

Tissue repair, contraction, and the myofibroblast

A Desmouliere et al.

WOUND REPAIR AND REGENERATION (2005)

Review Oncology

Notch signaling in development and disease

EM Hansson et al.

SEMINARS IN CANCER BIOLOGY (2004)

Article Medicine, Research & Experimental

Bone marrow-derived progenitor cells in pulmonary fibrosis

N Hashimoto et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)