期刊
CURRENT OPINION IN RHEUMATOLOGY
卷 24, 期 3, 页码 306-311出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0b013e3283521c4e
关键词
assay techniques; biological therapies; clinical implications; immunogenicity; therapeutic drug monitoring
类别
资金
- Genmab
- Pfizer (Wyeth)
Purpose of review To give an overview of the current knowledge on assay techniques and clinical implications of immunogenicity of biological therapeutics. Recent findings Assay techniques for the measurement of immunogenicity have improved, expanding the understanding of the immune response against biological therapeutics. Knowledge on the clinical effect of immunogenicity enables the treatment of patients in a targeted fashion, as a step towards personalized medicine. Summary Biological medications are able to induce an antidrug immune response. Immunogenicity impairs clinical response and is associated with adverse events. Several confounding factors influence the measurement of immunogenicity, including drug interference and background problems. Concomitant administration of methotrexate lowers the frequency and amount of antibodies formed, whereby the efficacy of biologicals is improved. Algorithms for therapeutic drug monitoring could aid in adapting treatment strategies in a controlled setting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据