期刊
CURRENT OPINION IN RHEUMATOLOGY
卷 23, 期 4, 页码 352-357出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0b013e3283477b7b
关键词
immunity; microbiome; periodontitis; porphyromonas; rheumatoid arthritis
类别
资金
- Canadian Institutes of Health Research [MOP 7770]
Purpose of review This review focuses on recent research that explores the role of infectious organisms in the development of autoimmunity and rheumatoid arthritis (RA). Recent findings Human and animal studies provide further evidence supporting a role for the periodontal pathogen, Porphyromonas gingivalis, in the development of RA. The microbiome plays a key role in the developing immune system. Alterations in the bowel microbiome lead to altered innate and adaptive immune responses potentially relevant to the development or persistence of RA. Summary Microbes and the host response to microbes are important factors in the maintenance of health. Abnormalities or imbalances in these responses can lead to the development of autoimmune inflammatory conditions such as RA.
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