期刊
CURRENT OPINION IN RHEUMATOLOGY
卷 21, 期 5, 页码 495-500出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0b013e32832effdd
关键词
antinuclear antibodies; complement; lupus-associated genes; primary antiphospholipid syndrome; systemic lupus erythematosus
类别
Purpose of review Although originally described in the context of systemic lupus erythematosus, antiphospholipid syndrome was then recognized as a primary antiphospholipid syndrome without any underlying autoimmune disease in almost half of the cases, However, cases of primary antiphospholipid syndrome were reported to evolve into systemic lupus erythematosus over time suggesting that these apparently different diseases are somehow related. Recent findings Peculiar biological systemic lupus erythematosus markers such as an autoantibody response against chromatin antigens and complement activation have been also described in patients with primary anti phospholipid syndrome. Distinct polymorphisms of common genetic factors have been associated with systemic lupus erythematosus and primary antiphospholipid syndrome supporting the notion that these entities are indeed variants within a continuum of the same disease. Summary A multiorgan involvement that cannot be explained by the thrombophilic state per se and similar to the well known clinical manifestations in lupus is reported in patients with primary antiphospholipid syndrome. Further studies, mainly genetic, will better underline the proximity between primary antiphospholipid syndrome and systemic lupus erythematosus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据