期刊
CURRENT OPINION IN PULMONARY MEDICINE
卷 15, 期 5, 页码 513-516出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCP.0b013e32832ea509
关键词
autoimmune pancreatitis; IgG4; interstitial lung disease
Purpose of review This review examines recent advances in our knowledge of the clinical pathological,, diagnostic, and therapeutic aspects of IgG4-related interstitial lung disease (ILD). Recent findings A recent case series of ILD with IgG4-positive plasma cells suggested grade 1 lymphomatoid granulomatosis. The presence of the IgG4-positive plasma cells with the lack of atypical cells favored IgG4-related ILD as a diagnosis. In another case study, four out of 30 patients with autoimmune pancreatitis developed pulmonary involvement during follow-up. Elevations of IgG4 and Krebs von den Lungen-6 levels were associated and thought to be predictive of the development of IgG4-related lung disease. A retrospective analysis investigating radiological/pathologic correlation in IgG4 lung disease identified computed tomographic features pathologically corresponding to IgG4-related sclerosing inflammation in the pulmonary interstitium. Summary IgG4-related ILD is a new and evolving entity. It can occur with or without systemic involvement. Larger studies are necessary to elucidate the exact mechanism and clinical characteristics of this disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据