期刊
CURRENT OPINION IN PSYCHIATRY
卷 22, 期 1, 页码 32-36出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YCO.0b013e328315a561
关键词
coronary syndromes; C-reactive protein; cytokines; inflammation; major depression
类别
资金
- Science Foundation Ireland
- Industrial Development Authority of Ireland
- Health Research Board (HRB) of Ireland
- Higher Education Authority (HEA) of Ireland
Purpose of review To provide a critical update of the literature linking depression and inflammation, together with possible underlying mechanisms and longer term risk of cardiovascular disease. Recent findings The current literature lends further support to the view that major depression is associated with a proinflammatory response, as indexed by elevation in C-reactive protein and cytokines such as interleukin 6 and tumour necrosis factor-a. Antidepressants suppress the inflammatory response, whereas electroconvulsive therapy acutely increases proinflammatory cytokine levels. Most, though not all, studies support a link between depression, inflammation and cardiovascular events. Summary Depression is an inflammatory state that may increase the risk of cardiac disease. Whether or not the immune system is an appropriate target for antidepressant development has yet to be established.
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