期刊
CURRENT OPINION IN PSYCHIATRY
卷 21, 期 2, 页码 157-160出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YCO.0b013e3282f4efde
关键词
genetics; genomewide association; genomewide linkage; schizophrenia
类别
资金
- NIMH NIH HHS [R01 MH074027, R01 MH074027-02, R01 MH074027-01A1] Funding Source: Medline
Purpose of review To describe the rationale for searching for genes for schizophrenia, prior efforts via candidate gene association and genomewide linkage studies, and to set the stage for the numerous genomewide association studies that will emerge by the end of 2008. Recent findings Genomewide association studies have identified dozens of new and previously unsuspected candidate genes for many biomedical disorders. At least seven new studies of approximately 20 000 cases plus controls are expected to be completed by the end of 2008. Summary Current results have few implications for clinical practice or research, and it is possible that this recommendation could be dramatically different in a year.
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