期刊
CURRENT OPINION IN PSYCHIATRY
卷 21, 期 2, 页码 140-150出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YCO.0b013e3282f51266
关键词
adolescence; diffusion tensor imaging; genes; marijuana; MRI; psychosis
类别
资金
- NIDA NIH HHS [R01 DA021576] Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA021576] Funding Source: NIH RePORTER
Purpose of review This review explores what is known about the association of cannabis with schizophrenia, its effects on the brain, and whether the brain changes known to be present in schizophrenia could be caused by cannabis and thus lead to a psychosis. Recent findings The heavy use of cannabis is known to be associated with some adverse consequences, such as the occurrence of acute psychotic episodes and the development of chronic schizophrenia in some people even after its use has terminated. Recent studies have produced controversy about whether cannabis in heavy use can cause irreversible brain damage, particularly to adolescents, and thus whether a chronic psychosis could be a result of brain changes caused by cannabis. Summary From the evidence that exists, it appears that the above view is unlikely and that cannabis may even have benign effects on brain structure, not producing deleterious damage. Its neurochemical interactions with the dopaminergic pathway, however, may, particularly in genetically vulnerable individuals, have adverse consequences.
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