期刊
CURRENT OPINION IN PLANT BIOLOGY
卷 15, 期 6, 页码 677-682出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2012.09.014
关键词
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资金
- National Science Foundation [MCB-1121994]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1121994] Funding Source: National Science Foundation
Ca2+ is a key player in an astonishing variety of plant signal transduction pathways where transient, spiking or oscillatory changes in cytosolic Ca2+ levels help to couple environmental or developmental cues to appropriate cellular responses. Understanding whether and how much Ca2+ signaling contributes to defining stimulus-response specificity has long been a challenge, but recent work has provided strong evidence that specific information can indeed be encoded in the spatiotemporal characteristics of Ca2+ signals. Identification of the Ca2+ binding proteins that transduce Ca2+ signals by regulating downstream effector proteins has revealed a complex network of Ca2+ sensor families, of which some members show distinct patterns of expression and subcellular localization. By utilizing genetically encoded fluorescent Ca2+ probes to monitor Ca2+ changes at high spatiotemporal resolution, it is now possible to explore whether such spatial heterogeneities in Ca2+ sensor distribution are coordinated with subcellular microdomains of Ca2+ signaling. Such visualization of Ca2+ signaling will also help to address which cellular compartments and transporters contribute to mobilizing and sequestering Ca2+ and thus define stimulus-specific Ca2+ signatures.
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