期刊
CURRENT OPINION IN PLANT BIOLOGY
卷 11, 期 5, 页码 486-494出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2008.06.003
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资金
- Ministerio de Educacion y Ciencia of Spain
- Comunidad de Madrid
- European Commission
- EMBO
- Portuguese FCT
Jasmonates (JAs) are essential hormones for plant defense and development. In spite of their importance, the molecular details of their signaling pathways remain largely unknown. A new family of regulators of JA signaling named JAZ, jasmonate ZIM-domain proteins, has recently been described. JAZ proteins repress of JA signaling and are targeted by the E3-ubiquitin ligase SCFCOI1 for proteasome degradation in response to JA. Hormone binding depends on a functional COI1 protein suggesting that COI1 is the JA receptor. MYC2, a positive regulator of JA-dependent responses, has been identified as a target of JAZ repressors. Interestingly, MYC2 and JAZ proteins are involved in a negative regulatory feedback loop, suggesting a model to explain how transcriptional reprogramming is turned on and off in response to JA. The discovery of JAZ repressors provides a new framework to understand JA-signaling pathways from hormonal perception to transcriptional activation.
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