期刊
CURRENT OPINION IN PHARMACOLOGY
卷 16, 期 -, 页码 50-57出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2014.03.002
关键词
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资金
- NIAID NIH HHS [R56 AI079236, R01 AI079236] Funding Source: Medline
beta-Blockers are used for a wide range of diseases from hypertension to glaucoma. In some diseases/conditions all beta-blockers are effective, while in others only certain subgroups are therapeutically beneficial. The best-documented example for only a subset of beta-blockers showing clinical efficacy is in heart failure, where members of the class have ranged from completely ineffective, to drugs of choice for treating the disease. Similarly, beta-blockers were tested in murine asthma models and two pilot clinical studies. A different subset was found to be effective for this clinical indication. These findings call into question the current system of classifying these drugs. To consider 'beta-blockers', as a single class is misleading when considering their rigorous pharmacological definition and their appropriate clinical application.
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