期刊
CURRENT OPINION IN PHARMACOLOGY
卷 13, 期 1, 页码 23-31出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2012.09.013
关键词
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资金
- National Eye Institute, Bethesda, MD [R01 EY013813, R01 EY017131]
- Robert W. Rounsavall, Jr. Family Foundation, Inc.
- Research to Prevent Blindness Inc., New York, NY
Although the immune system functions to preserve and restore tissue homeostasis, accumulating risk factors, prolonged glial activation, and sustained release of pro-inflammatory mediators in glaucoma may lead to a failure in the regulation of stress-induced immune response, and innate immune cells, autoreactive T cells, autoantibodies, and excess complement attack may exhibit potent stimuli that harm retinal ganglion cell somas, axons, and synapses. Identification of the cellular and molecular components of immune response pathways can provide immunomodulatory treatment strategies to attenuate neuroinflammation, protect neural tissue from collateral injury, and enhance endogenous recovery processes. This review highlights the current knowledge of molecular mechanisms regulating neuroinflammation in glaucoma.
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