期刊
CURRENT OPINION IN PHARMACOLOGY
卷 13, 期 6, 页码 900-908出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2013.10.001
关键词
-
资金
- DFG [Se 460/13-4, SFB621/C9]
The concept of a protective alkaline gastric and duodenal mucus layer is a century old, yet it is amazing how much new information on HCO3- transport pathways has emerged recently, made possible by the extensive utilization of gene-deleted and transgenic mice and novel techniques to study HCO3- transport. This review highlights recent findings regarding the importance of HCO3- for mucosal protection of duodenum and other gastrointestinal epithelia against luminal acid and other damaging factors. Recently, methods have been developed to visualize HCO3- transport in vivo by assessing the surface pH in the mucus layer, as well as the epithelial pH. New information about HCO3- transport pathways, and emerging concepts about the intricate regulatory network that governs duodenal HCO3- secretion are described, and new perspectives for drug therapy discussed.
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