期刊
CURRENT OPINION IN PHARMACOLOGY
卷 11, 期 2, 页码 156-161出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2010.12.001
关键词
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资金
- NHLBI NIH HHS [R01 HL039006, R01 HL039006-23, P01 HL058000-10, P01 HL058000] Funding Source: Medline
- NIDDK NIH HHS [F32 DK080575, F32 DK080575-01, F32 DK080575-02] Funding Source: Medline
In recent years a major research effort has focused on the role of inflammation, and in particular adaptive immunity, in the genesis of hypertension. Hypertension stimulates the accumulation of inflammatory cells including macrophages and T lymphocytes in peripheral tissues important in blood pressure control, such as the kidney and vasculature. Angiotensin II modulates blood pressure via actions on the central nervous system (CNS) and the adaptive immune system. Recent work suggests that the central actions of angiotensin II via the circumventricular organs lead to activation of circulating T-cells and vascular inflammation. The neuro-immune system plays an essential role in the pathogenesis of hypertension and further understanding of this relationship could lead to the development of new treatment strategies.
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