期刊
CURRENT OPINION IN PHARMACOLOGY
卷 11, 期 2, 页码 144-149出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2010.12.004
关键词
-
资金
- Heart, Lung and Blood Institute of NIH [PO1-HL62222]
The carotid body (CB) plays an important role in the control of breathing and in autonomic control of cardiovascular function. CB chemoreceptor activity is enhanced in chronic heat failure (CHF) and contributes to the sympathetic hyperactivity that exacerbates the progression of the disease. Studies in the past few years have revealed that a local angiotensin (Ang) system exists in the CB and plays an important role in altering CB function in CHF as well as other conditions, such as chronic hypoxia. This brief review highlights recent revelations that Ang I metabolites exert effects within the CB, and focuses on the influence of Ang II and Ang-(1-7) on CB function in CHF.
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