期刊
CURRENT OPINION IN PHARMACOLOGY
卷 11, 期 6, 页码 649-655出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2011.09.014
关键词
-
资金
- Fondation Leducq [06 CVD 02]
- British Heart Foundation [PG/07/091/23698]
- NSF-NIFI CRCNS [NIH R01 AA18060]
The cyclic adenosine 3',5'-monophosphate signalling pathway is now recognised to transduce signals in a compartmentalised manner such that individual stimuli only engage a subset of the pathway components that are physically constrained within defined subcellular locales, thus resulting in a precise functional outcome. As we are starting to appreciate the complexity of the spatial organisation and of the temporal regulation of this pathway, it is becoming clear that disruption of local signalling may lead to pathology and that local manipulation of cAMP signals may offer alternative approaches to treat disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据