期刊
CURRENT OPINION IN PHARMACOLOGY
卷 10, 期 2, 页码 185-190出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2009.11.007
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资金
- Deutsche Forschungsgemeinschaft [SCHA 1082/2-1]
- Else Kroner-Fresenius-Stiftung
Extracellular matrix (ECM) components, commonly thought to function purely as structural elements are now demonstrated to act as signaling molecules. With the identification of matrix-derived endogenous ligands of Toll-like and NOD-like receptors of innate immunity, a general question about the mechanisms of soluble ECM components signaling as autonomous triggers of sterile or enhancers of pathogen-mediated inflammation gained notable relevance. They act as fundamental danger signals signifying tissue injury by eliciting a robust proinflammatory response. Immense therapeutic potential resides in translating this knowledge into the development of Toll-like and NOD-like receptor inhibitors. This review focuses on the role of ECM-derived ligands of innate immunity receptors as mediators of renal inflammation and promising pharmacological targets in kidney disease.
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