期刊
CURRENT OPINION IN PHARMACOLOGY
卷 8, 期 6, 页码 765-776出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2008.09.005
关键词
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资金
- BBSRC Integrative Mammalian Biology Fund
- GlaxoSmithKline
- Ptizer
- BBSRC [BB/E52708X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E52708X/1] Funding Source: researchfish
Annexin A1 (ANXA1, formerly termed lipocortin 1 or macrocortin) is an important protein mediator of the feedback actions of glucocorticoids within the hypothalamo-pituitary-adrenocortical (HPA) axis. Here we consider the mechanisms by which ANXA1 exerts these actions, with particular reference to the potential role of the formyl peptide receptors (FPRs), a family of G-protein-coupled receptors which has only very recently been implicated in the regulation of neuroendocrine function. In addition, we discuss evidence that ANXA1 contributes to the regulation of other aspects of endocrine and metabolic function and to the aetiology of sexual dimorphisms.
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