期刊
CURRENT OPINION IN PHARMACOLOGY
卷 8, 期 1, 页码 8-13出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2007.09.009
关键词
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资金
- NINDS NIH HHS [R01 NS050567-01A1, P01 NS035965, 2P01 NS35965, R01 NS050567, R01 NS050567-02, 5R01 NS050567, R01 NS050567-03] Funding Source: Medline
Toll-like receptors (TLRs) are a family of evolutionarily conserved molecules that directly detect pathogen invasion or tissue damage and initiate a biological response. TLRs can signal through two primary intracellular pathways and as such can induce either immuno-stimulatory or immuno-modulatory molecules. Both sides of this twin-edged sword are being examined for their therapeutic potential in combating neurological disease. The immuno-stimulatory properties of TLRs are being used to generate tumor-specific immune responses to CNS tumors while the immuno-modulatory properties are being used to suppress damaging inflammatory responses to stroke. Recently, a third component of TLR signaling has begun to emerge-that of direct neuroprotection. Hence, the TLRs offer novel targets for the treatment of neurological disease.
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