期刊
CURRENT OPINION IN PEDIATRICS
卷 23, 期 2, 页码 161-166出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOP.0b013e3283423e51
关键词
antioxidants; oxidative stress; prematurity; reactive oxygen species
类别
资金
- NHLBI NIH HHS [R01 HL064158-01A1, R01 HL064158] Funding Source: Medline
- NIDA NIH HHS [R21 DA041706] Funding Source: Medline
Purpose of review This review will examine the unique susceptibility of premature infants to oxidative stress, the role of reactive oxygen species (ROS) in the pathogenesis of common disorders of the preterm infant, and potential for therapeutic interventions using enzymatic and/or nonenzymatic antioxidants. Recent findings Oxidative stress is caused by an imbalance between the production of ROS and the ability to detoxify them with the help of antioxidants. The premature infant is especially susceptible to ROS-induced damage because of inadequate antioxidant stores at birth, as well as impaired upregulation in response to oxidant stress. Thus, the premature infant is at increased risk for the development of ROS-induced diseases of the newborn, such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and periventricular leukomalacia. Summary Potential therapies for ROS-induced disease include both enzymatic and nonenzymatic antioxidant preparations. More research is required to determine the beneficial effects of supplemental antioxidant therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据