期刊
CURRENT OPINION IN ORGAN TRANSPLANTATION
卷 16, 期 1, 页码 15-20出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOT.0b013e32834253c7
关键词
apoptotic cells; complement; CRP; Fc receptors; PTX3; reperfusion injury; SAP
资金
- Department of Veterans Affairs
- National Institutes of Health
Purpose of review Ischemia/reperfusion injury and organ allograft rejection both entail excessive cell and tissue destruction. A number of innate immune proteins, including the pentraxins, participate in the removal of this potentially inflammatory and autoimmunogenic material. The classical pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP) are serum opsonins, which bind to damaged membranes and nuclear autoantigens. Understanding the role of pentraxins in inflammation has been advanced by the recent identification and structural analysis of their receptor interactions. Recent findings The ligand-binding, complement-activating and opsonic properties of pentraxins have been known for some time. However, the establishment of Fc gamma receptors as the primary receptors for pentraxins is a recent finding with important implications for CRP and SAP functions. The crystal structure of SAP in complex with Fc gamma RIIa was recently solved, leading to new insights into function and new opportunities for pentraxin-based therapeutics. In addition, new approaches to inhibit CRP synthesis or binding are being developed based on clinical associations between CRP levels and cardiovascular disease. Summary This review will summarize data on the function of pentraxins in clearance of injured tissue and cells and discuss the implications of this clearance pathway for autoimmunity and ischemia/reperfusion injury.
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