Rationale and criteria of eligibility for calcineurin inhibitor interruption following kidney transplantation

Purpose of review To summarize predictive low-risk parameters of renal allograft recipients for purposes of improving the initiation of calcineurin inhibitor withdrawal protocols. Recent findings Clinical trials have demonstrated the potential global benefit of calcineurin inhibitor interruption protocols on graft survival despite being associated with an increased rate of acute rejection episodes, thus underlying a number of risk factors. Recent identification or confirmation of variables updating the list of parameters and molecular markers that can be used to predict graft outcome are described. Summary The effect of calcineurin inhibitor withdrawal on long-term graft and recipient survival patterns is assessed in relation to the large number of calcineurin inhibitor-related side-effects. However, current protocols are based on empirical observations and there is a clear requirement for reliable parameters to define patient eligibility for calcineurin inhibitor weaning procedures. Here, we review biological, clinical and genetic parameters that can be used as predictive markers of long-term graft outcome and could serve as criteria for patient selection in calcineurin inhibitor weaning protocols.